What is the recommended onset-to-thrombectomy time window?

What is the recommended onset-to-thrombectomy time window?

• A. 24 hours
• B. 6 hours
• C. 12 hours
• D. 48 hours

Answer: (A)

The main idea is that the time window for thrombectomy isn’t a fixed cutoff for everyone. While treating within six hours is the standard goal for most patients, imaging-based selection can extend the window to up to twenty-four hours in certain cases. If the brain tissue shows a small infarct core with a large amount of salvageable penumbra, reperfusion can still yield meaningful benefits even after several hours. This extended window evidence comes from trials like DAWN and DEFUSE-3, which demonstrated improved outcomes with thrombectomy when imaging criteria indicate a favorable mismatch. Outside this extended window, the benefits aren’t clearly supported by the data. So, the recommended onset-to-thrombectomy window is up to twenty-four hours for patients who meet the imaging criteria.

The main idea is that the time window for thrombectomy isn’t a fixed cutoff for everyone. While treating within six hours is the standard goal for most patients, imaging-based selection can extend the window to up to twenty-four hours in certain cases. If the brain tissue shows a small infarct core with a large amount of salvageable penumbra, reperfusion can still yield meaningful benefits even after several hours. This extended window evidence comes from trials like DAWN and DEFUSE-3, which demonstrated improved outcomes with thrombectomy when imaging criteria indicate a favorable mismatch. Outside this extended window, the benefits aren’t clearly supported by the data. So, the recommended onset-to-thrombectomy window is up to twenty-four hours for patients who meet the imaging criteria.