What is the maximum total dose of Tenecteplase used for stroke treatment?

What is the maximum total dose of Tenecteplase used for stroke treatment?

• A. 15 mg
• B. 25 mg
• C. 35 mg
• D. 45 mg

Answer: (B)

Tenecteplase dosing for acute ischemic stroke is given as a single IV bolus at 0.25 mg/kg, with a maximum total dose of 25 mg. This cap is chosen because increasing the dose beyond 25 mg does not improve vessel opening but raises the risk of symptomatic intracranial hemorrhage. So, the practical limit is 25 mg, balancing effective clot breakdown with safety. Heavier patients reach the cap (for example, someone around 100 kg would receive 25 mg), while lighter patients get a proportional, lower dose. Doses like 15 mg are below the typical target for many patients, and doses such as 35 mg or 45 mg exceed the safe maximum.

Tenecteplase dosing for acute ischemic stroke is given as a single IV bolus at 0.25 mg/kg, with a maximum total dose of 25 mg. This cap is chosen because increasing the dose beyond 25 mg does not improve vessel opening but raises the risk of symptomatic intracranial hemorrhage. So, the practical limit is 25 mg, balancing effective clot breakdown with safety. Heavier patients reach the cap (for example, someone around 100 kg would receive 25 mg), while lighter patients get a proportional, lower dose. Doses like 15 mg are below the typical target for many patients, and doses such as 35 mg or 45 mg exceed the safe maximum.