Tenecteplase should be administered as which method?

Tenecteplase should be administered as which method?

• A. IV infusion over 60 minutes
• B. Subcutaneous injection
• C. IV bolus over 5 seconds
• D. Intramuscular injection

Answer: (C)

Tenecteplase is designed for rapid, single-dose reperfusion, so it is given as a one-time intravenous bolus. Administering it this way over about 5 seconds allows the drug to act quickly to dissolve the clot. Infusing over an hour would delay onset and isn’t how this medication is intended to work. Subcutaneous or intramuscular routes aren’t appropriate because they’re unreliable for delivering the dose quickly and can increase bleeding risk. The IV bolus approach provides the fastest, most reliable administration for thrombolysis.

Tenecteplase is designed for rapid, single-dose reperfusion, so it is given as a one-time intravenous bolus. Administering it this way over about 5 seconds allows the drug to act quickly to dissolve the clot. Infusing over an hour would delay onset and isn’t how this medication is intended to work. Subcutaneous or intramuscular routes aren’t appropriate because they’re unreliable for delivering the dose quickly and can increase bleeding risk. The IV bolus approach provides the fastest, most reliable administration for thrombolysis.